G17A (p.Gly17Ala) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
G17A (p.Gly17Ala) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G17A (p.Gly17Ala) variant details
- p.Gly17Ala
- ExAC rs769255133
- gnomAD rs769255133
- Missense
- Variant Prioritization Score for Impact Estimate 0.258
- REVEL 0.04
- ESM-1b 0.93
- AlphaMissense 0.10
- MetaLR 0.05
- MetaSVM -1.10
- CADD 17.10
- Most common in the Latino/Admixed American population (allele frequency 0.00011)
- Structural context available
- NEDD4L WW domain domainome 1.0: score -0.986