E77Q (p.Glu77Gln) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
E77Q (p.Glu77Gln) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes structural context.
E77Q (p.Glu77Gln) variant details
- p.Glu77Gln
- NCI-TCGA Cosmic COSV5684
- cosmic curated COSV56841
- NCI-TCGA Cosmic COSV9989
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.536
- REVEL 0.49
- ESM-1b 1.00
- AlphaMissense 0.76
- MetaLR 0.38
- MetaSVM -0.32
- SIFT 0.08
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available