E77* (p.Glu77Ter) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
E77* (p.Glu77Ter) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.88 / 1. The record also includes population frequency data and structural context.
E77* (p.Glu77Ter) variant details
- p.Glu77Ter
- rs1331870721
- NCI-TCGA Cosmic COSV5684
- NCI-TCGA Cosmic COSV9989
- cosmic curated COSV99895
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.876
- CADD 49.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Latino/Admixed American population (allele frequency 0.00011)
- Structural context available