E18G (p.Glu18Gly) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
E18G (p.Glu18Gly) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, experimental measurements, and structural context.
E18G (p.Glu18Gly) variant details
- p.Glu18Gly
- gnomAD rs1273725561
- Missense
- Variant Prioritization Score for Impact Estimate 0.327
- REVEL 0.21
- ESM-1b 0.00
- AlphaMissense 0.17
- MetaLR 0.12
- MetaSVM -0.96
- CADD 24.10
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- NEDD4L WW domain domainome 1.0: score -0.667