E16D (p.Glu16Asp) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
E16D (p.Glu16Asp) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
E16D (p.Glu16Asp) variant details
- p.Glu16Asp
- gnomAD 18-58044708-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.253
- REVEL 0.06
- ESM-1b 0.00
- AlphaMissense 0.11
- MetaLR 0.02
- MetaSVM -1.03
- CADD 23.80
- Population evidence available
- Structural context available
- NEDD4L WW domain domainome 1.0: score -1.57
- Literature evidence available