D42Y (p.Asp42Tyr) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
D42Y (p.Asp42Tyr) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.87 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D42Y (p.Asp42Tyr) variant details
- p.Asp42Tyr
- TOPMed rs1311632359
- Missense
- Variant Prioritization Score for Impact Estimate 0.87
- REVEL 0.87
- ESM-1b 1.00
- AlphaMissense 0.99
- MetaLR 0.79
- MetaSVM 0.76
- CADD 33.00
- Population evidence available
- Structural context available
- NEDD4L WW domain domainome 1.0: score -1.05