D15Y (p.Asp15Tyr) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
D15Y (p.Asp15Tyr) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes experimental measurements and structural context.
D15Y (p.Asp15Tyr) variant details
- p.Asp15Tyr
- ExAC rs12968145
- gnomAD rs12968145
- Missense
- Variant Prioritization Score for Impact Estimate 0.272
- REVEL 0.15
- ESM-1b 1.00
- AlphaMissense 0.32
- MetaLR 0.06
- MetaSVM -1.11
- SIFT 0.54
- Structural context available
- NEDD4L WW domain domainome 1.0: score -0.53