D15N (p.Asp15Asn) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
D15N (p.Asp15Asn) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D15N (p.Asp15Asn) variant details
- p.Asp15Asn
- rs12968145
- NCI-TCGA Cosmic COSV9989
- cosmic curated COSV99896
- ExAC rs12968145
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.332
- ESM-1b 0.38
- AlphaMissense 0.38
- MetaLR 0.06
- MetaSVM -1.11
- PolyPhen-2 0.09
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available
- NEDD4L WW domain domainome 1.0: score -0.53