D15E (p.Asp15Glu) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
D15E (p.Asp15Glu) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
D15E (p.Asp15Glu) variant details
- p.Asp15Glu
- gnomAD 18-58044705-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.143
- REVEL 0.07
- ESM-1b 0.00
- AlphaMissense 0.07
- MetaLR 0.04
- MetaSVM -1.06
- CADD 11.50
- Most common in the East Asian population (allele frequency 0.0015)
- Structural context available
- NEDD4L WW domain domainome 1.0: score -0.53
- Literature evidence available