D109Y (p.Asp109Tyr) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
D109Y (p.Asp109Tyr) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data and structural context.
D109Y (p.Asp109Tyr) variant details
- p.Asp109Tyr
- gnomAD rs1228729549
- Missense
- Variant Prioritization Score for Impact Estimate 0.706
- REVEL 0.65
- ESM-1b 1.00
- AlphaMissense 0.99
- MetaLR 0.47
- MetaSVM -0.10
- CADD 32.00
- Most common in the HGDP:SARDINIAN population (allele frequency 0.056)
- Structural context available