F35L (p.Phe35Leu) variant of NCF4 (Neutrophil cytosol factor 4)
F35L (p.Phe35Leu) in NCF4 (Neutrophil cytosol factor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
F35L (p.Phe35Leu) variant details
- p.Phe35Leu
- ExAC rs758660640
- gnomAD rs758660640
- Missense
- Variant Prioritization Score for Impact Estimate 0.423
- REVEL 0.32
- MetaLR 0.20
- MetaSVM -0.75
- CADD 25.00
- PolyPhen-2 1.00
- SIFT 0.21
- Most common in the 1KG:MXL population (allele frequency 0.0081)
- Structural context available