L9F (p.Leu9Phe) variant of NCF2 (Neutrophil cytosol factor 2)
L9F (p.Leu9Phe) in NCF2 (Neutrophil cytosol factor 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L9F (p.Leu9Phe) variant details
- p.Leu9Phe
- gnomAD rs1391299879
- Missense
- Variant Prioritization Score for Impact Estimate 0.451
- REVEL 0.36
- MetaLR 0.30
- MetaSVM -0.16
- CADD 23.40
- PolyPhen-2 0.03
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available
- NCF2 SH3 domain domainome 1.0: score -0.93