L15P (p.Leu15Pro) variant of NCF2 (Neutrophil cytosol factor 2)
L15P (p.Leu15Pro) in NCF2 (Neutrophil cytosol factor 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L15P (p.Leu15Pro) variant details
- p.Leu15Pro
- gnomAD rs1379367905
- Missense
- Variant Prioritization Score for Impact Estimate 0.534
- REVEL 0.53
- MetaLR 0.34
- MetaSVM -0.59
- CADD 22.50
- PolyPhen-2 0.42
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available
- NCF2 SH3 domain domainome 1.0: score -0.617