L112P (p.Leu112Pro) variant of NCF2 (Neutrophil cytosol factor 2)
L112P (p.Leu112Pro) in NCF2 (Neutrophil cytosol factor 2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
L112P (p.Leu112Pro) variant details
- p.Leu112Pro
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.605
- REVEL 0.68
- MetaLR 0.34
- MetaSVM -0.25
- CADD 24.10
- PolyPhen-2 0.24
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)
- Structural context available