P21R (p.Pro21Arg) variant of MYO15A (Unconventional myosin-XV)
P21R (p.Pro21Arg) in MYO15A (Unconventional myosin-XV) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
P21R (p.Pro21Arg) variant details
- p.Pro21Arg
- cosmic curated COSV11322
- ExAC rs747762338
- TOPMed rs747762338
- gnomAD rs747762338
- Missense
- Variant Prioritization Score for Impact Estimate 0.342
- REVEL 0.26
- ESM-1b 0.60
- AlphaMissense 0.32
- CADD 18.10
- PolyPhen-2 0.51
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available