P21L (p.Pro21Leu) variant of MYO15A (Unconventional myosin-XV)
P21L (p.Pro21Leu) in MYO15A (Unconventional myosin-XV) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
P21L (p.Pro21Leu) variant details
- p.Pro21Leu
- ExAC rs747762338
- TOPMed rs747762338
- gnomAD rs747762338
- Missense
- Variant Prioritization Score for Impact Estimate 0.331
- REVEL 0.23
- ESM-1b 0.77
- AlphaMissense 0.32
- CADD 15.00
- PolyPhen-2 0.26
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available