L63I (p.Leu63Ile) variant of MYO15A (Unconventional myosin-XV)
L63I (p.Leu63Ile) in MYO15A (Unconventional myosin-XV) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, published literature, and structural context.
L63I (p.Leu63Ile) variant details
- p.Leu63Ile
- gnomAD 17-18118987-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.473
- REVEL 0.35
- ESM-1b 0.00
- AlphaMissense 0.50
- CADD 24.40
- PolyPhen-2 0.94
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available