L63F (p.Leu63Phe) variant of MYO15A (Unconventional myosin-XV)
L63F (p.Leu63Phe) in MYO15A (Unconventional myosin-XV) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
L63F (p.Leu63Phe) variant details
- p.Leu63Phe
- gnomAD rs1202012319
- Missense
- Variant Prioritization Score for Impact Estimate 0.454
- REVEL 0.31
- ESM-1b 0.00
- AlphaMissense 0.76
- CADD 23.40
- PolyPhen-2 0.97
- SIFT 0.15
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available