F60L (p.Phe60Leu) variant of MYO15A (Unconventional myosin-XV)
F60L (p.Phe60Leu) in MYO15A (Unconventional myosin-XV) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
F60L (p.Phe60Leu) variant details
- p.Phe60Leu
- ExAC rs763250174
- gnomAD rs763250174
- Missense
- Variant Prioritization Score for Impact Estimate 0.402
- REVEL 0.40
- ESM-1b 0.00
- AlphaMissense 0.98
- CADD 21.50
- PolyPhen-2 0.01
- SIFT 0.19
- Most common in the South Asian population (allele frequency 0.0001)
- Structural context available