I21M (p.Ile21Met) variant of MYH11 (Myosin-11)
I21M (p.Ile21Met) in MYH11 (Myosin-11) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
I21M (p.Ile21Met) variant details
- p.Ile21Met
- ExAC rs755935176
- TOPMed rs755935176
- gnomAD rs755935176
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.243
- REVEL 0.20
- CADD 14.70
- PolyPhen-2 0.00
- SIFT 0.17
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available