Y36H (p.Tyr36His) variant of MYCN (N-myc proto-oncogene protein)
Y36H (p.Tyr36His) in MYCN (N-myc proto-oncogene protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
Y36H (p.Tyr36His) variant details
- p.Tyr36His
- Ensembl rs2103323641
- Missense
- Variant Prioritization Score for Impact Estimate 0.383
- REVEL 0.22
- MetaLR 0.22
- MetaSVM -0.63
- CADD 28.90
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available