S5F (p.Ser5Phe) variant of MYCN (N-myc proto-oncogene protein)

Name: MYCN S5F (p.Ser5Phe) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-19
License: https://catvariant.com/terms-of-use

S5F (p.Ser5Phe) in MYCN (N-myc proto-oncogene protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, published literature, and structural context.

S5F (p.Ser5Phe) variant details

p.Ser5Phe
gnomAD 2-15942078-C-T
Missense
Variant Prioritization Score for Impact Estimate 0.393
REVEL 0.38
MetaLR 0.28
MetaSVM -0.76
CADD 20.80
PolyPhen-2 0.00
SIFT 0.00
Most common in the REMAINING population (allele frequency 1.7e-05)
Structural context available
Literature evidence available