P10L (p.Pro10Leu) variant of MYCN (N-myc proto-oncogene protein)
P10L (p.Pro10Leu) in MYCN (N-myc proto-oncogene protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, published literature, and structural context.
P10L (p.Pro10Leu) variant details
- p.Pro10Leu
- gnomAD 2-15942093-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.486
- REVEL 0.34
- MetaLR 0.18
- MetaSVM -1.04
- CADD 28.30
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 6.3e-06)
- Structural context available
- Literature evidence available