F35Y (p.Phe35Tyr) variant of MYCN (N-myc proto-oncogene protein)
F35Y (p.Phe35Tyr) in MYCN (N-myc proto-oncogene protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, published literature, and structural context.
F35Y (p.Phe35Tyr) variant details
- p.Phe35Tyr
- gnomAD 2-15942168-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.455
- REVEL 0.36
- MetaLR 0.23
- MetaSVM -0.93
- CADD 29.20
- PolyPhen-2 0.91
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available