F35L (p.Phe35Leu) variant of MYCN (N-myc proto-oncogene protein)
F35L (p.Phe35Leu) in MYCN (N-myc proto-oncogene protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
F35L (p.Phe35Leu) variant details
- p.Phe35Leu
- ExAC rs766296336
- TOPMed rs766296336
- gnomAD rs766296336
- Missense
- Variant Prioritization Score for Impact Estimate 0.404
- REVEL 0.27
- MetaLR 0.16
- MetaSVM -0.87
- CADD 26.00
- PolyPhen-2 0.52
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available