F21Y (p.Phe21Tyr) variant of MYCN (N-myc proto-oncogene protein)
F21Y (p.Phe21Tyr) in MYCN (N-myc proto-oncogene protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
F21Y (p.Phe21Tyr) variant details
- p.Phe21Tyr
- Ensembl rs2103323385
- Missense
- Variant Prioritization Score for Impact Estimate 0.369
- REVEL 0.24
- MetaLR 0.04
- MetaSVM -1.11
- CADD 25.30
- PolyPhen-2 0.99
- SIFT 0.10
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available