C4G (p.Cys4Gly) variant of MYCN (N-myc proto-oncogene protein)
C4G (p.Cys4Gly) in MYCN (N-myc proto-oncogene protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
C4G (p.Cys4Gly) variant details
- p.Cys4Gly
- ExAC rs748156396
- gnomAD rs748156396
- Missense
- Variant Prioritization Score for Impact Estimate 0.366
- REVEL 0.28
- MetaLR 0.34
- MetaSVM -0.75
- CADD 22.60
- PolyPhen-2 0.01
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available