N26S (p.Asn26Ser) variant of MYC (Myc proto-oncogene protein)
N26S (p.Asn26Ser) in MYC (Myc proto-oncogene protein) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided; Classic Hodgkin lymphoma. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data, published literature, and structural context.
N26S (p.Asn26Ser) variant details
- p.Asn26Ser
- rs4645959
- ClinGen CA4875220
- cosmic curated COSV52371
- ClinVar RCV002227948
- Uncertain significance
- not provided; Classic Hodgkin lymphoma
- Missense
- Variant Prioritization Score for Impact Estimate 0.588
- CADD 26.70
- PolyPhen-2 0.16
- SIFT 0.01
- ClinVar: Uncertain significance (not provided; Classic Hodgkin lymphoma)
- EBI: Benign (in dbSNP:rs4645959)
- UniProt: Benign (in dbSNP:rs4645959)
- Most common in the HGDP:BASQUE population (allele frequency 0.16)
- Structural context available
- Literature evidence available