F22V (p.Phe22Val) variant of MYC (Myc proto-oncogene protein)
F22V (p.Phe22Val) in MYC (Myc proto-oncogene protein) is a missense change. Clinical records from EBI and UniProt describe it as benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
F22V (p.Phe22Val) variant details
- p.Phe22Val
- 1000Genomes rs146505192
- ESP rs146505192
- ExAC rs146505192
- TOPMed rs146505192
- Benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.562
- CADD 22.70
- PolyPhen-2 0.13
- SIFT 0.11
- EBI: Benign
- UniProt: Benign
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available