F22L (p.Phe22Leu) variant of MYC (Myc proto-oncogene protein)
F22L (p.Phe22Leu) in MYC (Myc proto-oncogene protein) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as benign/likely benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
F22L (p.Phe22Leu) variant details
- p.Phe22Leu
- rs146505192
- ClinGen CA4875217
- cosmic curated COSV52370
- ClinVar RCV000896531
- Benign/Likely benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.534
- CADD 18.80
- PolyPhen-2 0.01
- SIFT 1.00
- ClinVar: Benign/Likely benign (not provided)
- EBI: Benign
- UniProt: Benign
- Most common in the Ashkenazi Jewish population (allele frequency 0.046)
- Structural context available