T61S (p.Thr61Ser) variant of MTOR (P42345)
T61S (p.Thr61Ser) in MTOR (P42345) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
T61S (p.Thr61Ser) variant details
- p.Thr61Ser
- ExAC rs756658424
- gnomAD rs756658424
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.326
- REVEL 0.13
- CADD 22.30
- PolyPhen-2 0.02
- SIFT 0.32
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available