N68K (p.Asn68Lys) variant of MTOR (P42345)
N68K (p.Asn68Lys) in MTOR (P42345) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
N68K (p.Asn68Lys) variant details
- p.Asn68Lys
- ExAC rs767996746
- gnomAD rs767996746
- NCI-TCGA Cosmic COSV6386
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.38
- REVEL 0.25
- CADD 25.60
- PolyPhen-2 0.99
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available