G32S (p.Gly32Ser) variant of MSH6 (DNA mismatch repair protein Msh6)
G32S (p.Gly32Ser) in MSH6 (DNA mismatch repair protein Msh6) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided; Hereditary nonpolyposis colorectal neoplasms; Hereditary cancer-pr. The record also includes published literature and structural context.
G32S (p.Gly32Ser) variant details
- p.Gly32Ser
- rs776859837
- ClinGen CA346734825
- ClinVar RCV002015237
- ClinVar RCV002269387
- Uncertain significance
- not provided; Hereditary nonpolyposis colorectal neoplasms; Hereditary cancer-pr
- Missense
- ClinVar: Uncertain significance (not provided; Hereditary nonpolyposis colorectal neoplasms; Here)
- EBI: Likely benign
- UniProt: Likely benign
- Structural context available
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)