p.Ser16dup variant of MSH3 (DNA mismatch repair protein Msh3)

Name: MSH3 p.Ser16dup variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-21
License: https://catvariant.com/terms-of-use

p.Ser16dup in MSH3 (DNA mismatch repair protein Msh3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data, published literature, and structural context.

p.Ser16dup variant details

rs1254174829
gnomAD 5-80654764-G-GCCT
Inframe Insertion
Variant Prioritization Score for Impact Estimate 0.695
CADD 10.20
Most common in the East Asian population (allele frequency 2.6e-05)
Structural context available
Literature evidence available