S25S (p.Ser25Ser) variant of MSH3 (DNA mismatch repair protein Msh3)
S25S (p.Ser25Ser) in MSH3 (DNA mismatch repair protein Msh3) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, published literature, and structural context.
S25S (p.Ser25Ser) variant details
- p.Ser25Ser
- rs879145456
- gnomAD 5-80654802-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.473
- AlphaMissense 0.62
- MetaLR 0.67
- MetaSVM 0.19
- CADD 15.10
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available