S25R (p.Ser25Arg) variant of MSH3 (DNA mismatch repair protein Msh3)
S25R (p.Ser25Arg) in MSH3 (DNA mismatch repair protein Msh3) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes structural context.
S25R (p.Ser25Arg) variant details
- p.Ser25Arg
- rs879145456
- ClinGen CA360265215
- ClinVar RCV001230805
- Ensembl rs879145456
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.622
- AlphaMissense 0.62
- MetaLR 0.67
- MetaSVM 0.19
- PolyPhen-2 1.00
- SIFT 0.00
- MutPred 0.34
- ClinVar: Uncertain significance (not provided)
- EBI: Likely benign
- UniProt: Likely benign
- Structural context available