G25A (p.Gly25Ala) variant of MSH2 (DNA mismatch repair protein Msh2)
G25A (p.Gly25Ala) in MSH2 (DNA mismatch repair protein Msh2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, published literature, and structural context.
G25A (p.Gly25Ala) variant details
- p.Gly25Ala
- gnomAD 2-47403265-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.257
- REVEL 0.24
- ESM-1b 0.00
- AlphaMissense 0.08
- CADD 20.50
- PolyPhen-2 0.00
- SIFT 0.16
- Most common in the HGDP:BANTUSOUTHAFRICA population (allele frequency 0.062)
- Structural context available
- Literature evidence available