V28V (p.Val28Val) variant of MPL (Thrombopoietin receptor)
V28V (p.Val28Val) in MPL (Thrombopoietin receptor) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
V28V (p.Val28Val) variant details
- p.Val28Val
- gnomAD 1-43338103-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.286
- CADD 8.81
- Population evidence available
- Structural context available
- TpoR activation by low dosage of Tpo: score 0.906
- Literature evidence available