V23V (p.Val23Val) variant of MPL (Thrombopoietin receptor)
V23V (p.Val23Val) in MPL (Thrombopoietin receptor) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
V23V (p.Val23Val) variant details
- p.Val23Val
- gnomAD 1-43337917-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.305
- CADD 11.30
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available
- TpoR activation by low dosage of Tpo: score 1.18
- Literature evidence available