S42Y (p.Ser42Tyr) variant of MPL (Thrombopoietin receptor)
S42Y (p.Ser42Tyr) in MPL (Thrombopoietin receptor) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The record also includes experimental measurements and structural context.
S42Y (p.Ser42Tyr) variant details
- p.Ser42Tyr
- NCI-TCGA Cosmic COSV1009
- cosmic curated COSV10099
- Variant assessed as somatic; moderate impact.
- Missense
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available
- TpoR activation by low dosage of eltrombopag: score 0.819