S3S (p.Ser3Ser) variant of MPL (Thrombopoietin receptor)

Name: MPL S3S (p.Ser3Ser) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-18
License: https://catvariant.com/terms-of-use

S3S (p.Ser3Ser) in MPL (Thrombopoietin receptor) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.

S3S (p.Ser3Ser) variant details

p.Ser3Ser
gnomAD 1-43337857-C-G
Synonymous
Variant Prioritization Score for Impact Estimate 0.21
CADD 7.11
Population evidence available
Structural context available
TpoR activation by high dosage of lusutrombopag: score 0.739
Literature evidence available