P37P (p.Pro37Pro) variant of MPL (Thrombopoietin receptor)
P37P (p.Pro37Pro) in MPL (Thrombopoietin receptor) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
P37P (p.Pro37Pro) variant details
- p.Pro37Pro
- rs142697469
- gnomAD 1-43338130-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.216
- CADD 8.48
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- TpoR activation by low dosage of Tpo: score 0.851
- Literature evidence available