L38L (p.Leu38Leu) variant of MPL (Thrombopoietin receptor)
L38L (p.Leu38Leu) in MPL (Thrombopoietin receptor) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L38L (p.Leu38Leu) variant details
- p.Leu38Leu
- gnomAD 1-43338131-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.384
- CADD 9.41
- Population evidence available
- Structural context available
- TpoR activation by low dosage of romi-peptide: score 1.16
- Literature evidence available