L20L (p.Leu20Leu) variant of MPL (Thrombopoietin receptor)
L20L (p.Leu20Leu) in MPL (Thrombopoietin receptor) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L20L (p.Leu20Leu) variant details
- p.Leu20Leu
- rs756165019
- gnomAD 1-43337908-G-A
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.417
- CADD 9.44
- Population evidence available
- Structural context available
- TpoR activation by high dosage of lusutrombopag: score 1.06
- Literature evidence available