L15L (p.Leu15Leu) variant of MPL (Thrombopoietin receptor)
L15L (p.Leu15Leu) in MPL (Thrombopoietin receptor) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L15L (p.Leu15Leu) variant details
- p.Leu15Leu
- gnomAD 1-43337893-G-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.338
- CADD 8.85
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- TpoR activation by low dosage of Tpo: score 0.587
- Literature evidence available