F7F (p.Phe7Phe) variant of MPL (Thrombopoietin receptor)
F7F (p.Phe7Phe) in MPL (Thrombopoietin receptor) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
F7F (p.Phe7Phe) variant details
- p.Phe7Phe
- gnomAD 1-43337869-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.245
- CADD 7.74
- Population evidence available
- Structural context available
- TpoR activation by high dosage of lusutrombopag: score 0.726
- Literature evidence available