A21T (p.Ala21Thr) variant of MPL (Thrombopoietin receptor)
A21T (p.Ala21Thr) in MPL (Thrombopoietin receptor) is a missense change. The record also includes variant effect predictions, experimental measurements, and structural context.
A21T (p.Ala21Thr) variant details
- p.Ala21Thr
- gnomAD rs1162488972
- Missense
- MetaLR 0.26
- MetaSVM -0.78
- SIFT 0.20
- Structural context available
- TpoR activation by low dosage of Tpo: score 1.25