A16V (p.Ala16Val) variant of MPL (Thrombopoietin receptor)
A16V (p.Ala16Val) in MPL (Thrombopoietin receptor) is a missense change. The record also includes variant effect predictions, experimental measurements, and structural context.
A16V (p.Ala16Val) variant details
- p.Ala16Val
- gnomAD rs1476891431
- Missense
- MetaLR 0.25
- MetaSVM -0.91
- SIFT 0.23
- Structural context available
- TpoR activation by high dosage of lusutrombopag: score 1.14