Y73C (p.Tyr73Cys) variant of MLH3 (DNA mismatch repair protein Mlh3)
Y73C (p.Tyr73Cys) in MLH3 (DNA mismatch repair protein Mlh3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.82 / 1. The record also includes population frequency data and structural context.
Y73C (p.Tyr73Cys) variant details
- p.Tyr73Cys
- gnomAD rs1350361020
- Missense
- Variant Prioritization Score for Impact Estimate 0.818
- REVEL 0.93
- CADD 28.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the 1KG:MXL population (allele frequency 0.0081)
- Structural context available