I34T (p.Ile34Thr) variant of MLH3 (DNA mismatch repair protein Mlh3)
I34T (p.Ile34Thr) in MLH3 (DNA mismatch repair protein Mlh3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
I34T (p.Ile34Thr) variant details
- p.Ile34Thr
- TOPMed rs1008661571
- Missense
- Variant Prioritization Score for Impact Estimate 0.612
- REVEL 0.59
- CADD 26.50
- PolyPhen-2 0.94
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00031)
- Structural context available